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Review
. 2014 Sep;46(9):767-71.
doi: 10.1055/s-0034-1377508. Epub 2014 Aug 18.

Esophageal diseases

W Asher Wolf  1 , Evan S Dellon  1 , Nicholas J Shaheen  1
Affiliations
Review

Esophageal diseases

W Asher Wolf et al. Endoscopy. 2014 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Specimens obtained from the Cytosponge from two patients demonstrating the extensive amount of tissue that can be obtained with this technique. Panels (A) and (C) show esophageal tissue samples stained with routine H&E for each of the patients. Panels (B) and (D) show markedly increased immunohistochemical staining for eotaxin-derived neurotoxin for the same specimens. Courtesy of David Katzka.
Figure 2
Figure 2
Sample obtained by WATS demonstrating high grade dysplasia with nuclear hyperchromasia, irregular thick nuclear membranes, increased nuclear to cytoplasmic ratio, overlapping nuclei, and loss of nuclear polarity. Courtesy of Seth Gross.
Figure 3
Figure 3
(L) Median hours with distal esophageal pH <4 prior to implantation of electrical stimulator (gray) and at six- and twelve-months post-implantation (blue). (R) Median GERD-HRQL Scores on and off PPI (gray) and six- and twelve-months after implantation (blue). Error bars represent interquartile range. Courtesy of Peter Siersma.
Figure 4
Figure 4
Immunohistochemical staining demonstrates increased staining for CHN1 and TNFAIP3 with dysplasia and malignant transformation. Courtesy of Pierre Lao-Sirieix.
See this image and copyright information in PMC

References

    1. Dellon ES, Gonsalves N, Hirano I, Furuta GT, Liacouras CA, Katzka DA, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) Am J Gastroenterol. 2013 May;108(5):679–692. quiz 693. - PubMed
    1. Wolf WA, Jerath MR, Sperry SL, Shaheen NJ, Dellon ES. Dietary Elimination Therapy is an Effective Option for Adults with Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2014 In Press. - PMC - PubMed
    1. Katzka DA, Ravi A, Geno DM, Smyrk TC, Kita H, Lao-Sirieix P, et al. Cytosponge Evaluation of Eosinophilic Esophagitis in Comparison to Endoscopy: Accuracy, Safety and Tolerability. Gastroenterology. 2014;146(5):S16. - PubMed
    1. Kadri SR, Lao-Sirieix P, O'Donovan M, Debiram I, Das M, Blazeby JM, et al. Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study. BMJ. 2010 Sep 10;341:c4372. - PMC - PubMed
    1. American Gastroenterological Association. American Gastroenterological Association medical position statement on the management of Barrett's esophagus. Gastroenterology. 2011;140(3):1084–1091. - PubMed