Review
doi: 10.1016/0024-3205(89)90537-7.
Molecular pharmacology of muscarinic receptor heterogeneity
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- PMID: 2513460
- DOI: 10.1016/0024-3205(89)90537-7
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Review
Molecular pharmacology of muscarinic receptor heterogeneity
Life Sci.
1989.
Erratum in
- Life Sci 1990;46(6):461
Abstract
Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarinic receptor types and G proteins may depend on the systems in which the receptors are integrated. Expression of the cloned gene in mammalian cells will be useful in delineating the relationships between the pharmacological types of muscarinic receptors and their genes and studying the interactions between the receptor, G proteins, and second messenger coupling.
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