Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells--response

Affiliations

¹ Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
² Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
³ Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
⁴ Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tkkohno@ncc.go.jp.

Comment

Takahiro Oike et al. Cancer Res. 2014.

. 2014 Sep 1;74(17):4948-9.

doi: 10.1158/0008-5472.CAN-14-0674. Epub 2014 Aug 18.

¹ Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
² Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
³ Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
⁴ Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. tkkohno@ncc.go.jp.

No abstract available

Comment on

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.
Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T. Oike T, et al. Cancer Res. 2013 Sep 1;73(17):5508-18. doi: 10.1158/0008-5472.CAN-12-4593. Epub 2013 Jul 19. Cancer Res. 2013. PMID: 23872584
A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1--letter.
Thompson KW, Marquez SB, Reisman D. Thompson KW, et al. Cancer Res. 2014 Sep 1;74(17):4946-7. doi: 10.1158/0008-5472.CAN-13-2457. Epub 2014 Aug 18. Cancer Res. 2014. PMID: 25136073 No abstract available.