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. 2014 Nov;22(11):2441-9.
doi: 10.1002/oby.20867. Epub 2014 Aug 18.

Metabolic characterization of adults with binge eating in the general population: the Framingham Heart Study

Tobin M Abraham  1 , Joseph M Massaro, Udo Hoffmann, Jack A Yanovski, Caroline S Fox
Affiliations

Metabolic characterization of adults with binge eating in the general population: the Framingham Heart Study

Tobin M Abraham et al. Obesity (Silver Spring). 2014 Nov.

Abstract

Objective: To describe the metabolic profile of individuals with objective binge eating (OBE) and to evaluate whether associations between OBE and metabolic risk factors are mediated by body mass index (BMI).

Methods: Participants from the Framingham Heart Study, Third Generation and Omni 2 cohorts (n = 3,551, 53.1% women, mean age 46.4 years) were screened for binge eating. Multivariable-adjusted regression models to examine the associations of OBE with metabolic risk factors were used.

Results: The prevalence of OBE was 4.8% in women and 4.9% in men. Compared to non-binge eating, OBE was associated with higher odds of hypertension (OR 1.85, 95% CI 1.32-2.60), hypertriglyceridemia (OR 1.42, 95% CI 1.01-2.01), low HDL (OR 1.70, 95% CI 1.18-2.44), insulin resistance (OR 3.18, 95% CI 2.25-4.50) and metabolic syndrome (OR 2.75, 95% CI 1.94-3.90). Fasting glucose was 7.2 mg dl(-1) higher in those with OBE (P = 0.0001). Individuals with OBE had more visceral, subcutaneous and liver fat. Most of these associations were attenuated with adjustment for BMI, with the exception of fasting glucose.

Conclusions: Binge eating is associated with a high burden of metabolic risk factors. Much of the associated risk appears to be mediated by BMI, with the exception of fasting glucose.

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Conflict of interest statement

Disclosures: The authors have no conflicts to disclose.

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