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Comment
. 2014 Aug 18;24(16):R746-9.
doi: 10.1016/j.cub.2014.07.006.

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Fernando R Balestra  1 , Pierre Gönczy  2
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Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Fernando R Balestra et al. Curr Biol. .
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Abstract

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key component of a regulatory complex that activates the transcription of genes required for centriole formation.

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