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Case Reports
. 2015 Aug;3(3):243-53.
doi: 10.1093/gastro/gou054. Epub 2014 Aug 19.

Hypomagnesaemia associated with long-term use of proton pump inhibitors

James Wei Tatt Toh  1 , Evonne Ong  2 , Robert Wilson  3
Affiliations
Case Reports

Hypomagnesaemia associated with long-term use of proton pump inhibitors

James Wei Tatt Toh et al. Gastroenterol Rep (Oxf). 2015 Aug.

Abstract

Hypomagnesaemia and associated hypocalcaemia and hypoparathyroidism have been increasingly recognised as rare long-term side-effects of proton pump inhibitors (PPIs). The PPIs may inhibit active magnesium (Mg) absorption by interfering with transcellular transient receptor potential melastatin-6 and -7 (TRPM 6 and 7) channels. More recent cell culture studies have suggested concomitant inhibition of passive Mg absorption by omeprazole. After being treated with a range of PPIs, the four patients in our case series developed hypomagnesaemia, which responded to withdrawal of therapy and initiation of Mg replacement. Their clinical course and management demonstrate key aspects of hypomagnesaemia associated with long-term use of PPIs.

Keywords: Proton pump inhibitors; hypocalcaemia; hypomagnesaemia.

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Figures

Figure 1
Figure 1
Serum parathyroid hormone (PTH), calcium and magnesium for Case 1.
Figure 2
Figure 2
Serum parathyroid hormone (PTH), calcium and magnesium for Case 2.
Figure 3
Figure 3
Serum parathyroid hormone (PTH), calcium and magnesium for Case 3.
Figure 4
Figure 4
Serum parathyroid hormone (PTH), calcium and magnesium for Case 4.
See this image and copyright information in PMC

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