Rapid, de novo development of isolated intracranial rosai-dorfman disease: A case report

Abstract

Isolated intracranial Rosai-Dorfman Disease is rare. Here, we describe a patient who developed an asymptomatic, right parietal RDD lesion over 18 months while being followed radiographically for another brain lesion. To our knowledge, rapid, de novo radiographic formation of isolated intracranial RDD has never been reported in an asymptomatic patient.

Keywords: development; intracranial; isolated; rosai-dorfman disease; sinus histiocytosis with massive lymphadenopathy.

Fig. 1.

MR imaging shows a new, lobulated, extra-axial, duralbased mass in the right posterior parietal area. The lesion is seen as isointense to gray matter on T1-weighted sequences (A) with avid, homogeneous contrast enhancement (B) and isointense on T2-weighted (C) and fluid-attenuated inversion recovery sequences (D).

Fig. 2.

Histopathology and immunohistochemistry of the right posterior parietal lesion. Hematoxylin and eosin (H&E) staining (A, low magnification) shows scattered, often multinucleated, foamy histiocytes with a dense network of lymphoplasmacytic cells and occasional emperipolesis (B, high magnification, arrowhead). Cells stained strongly with CD68 (C) and S100 (D), but not with CD1α (not shown).