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. 2014 Aug 8:9:3719-35.
doi: 10.2147/IJN.S61670. eCollection 2014.

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Giovana Calixto  1 , Jéssica Bernegossi  1 , Bruno Fonseca-Santos  1 , Marlus Chorilli  1
Affiliations

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Giovana Calixto et al. Int J Nanomedicine. .

Abstract

Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.

Keywords: oral cancer treatment; oral squamous cell carcinoma; targeted delivery.

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Figures

Figure 1
Figure 1
Schematic differences between nanocapsule, nanostructured lipid carrier (NLC), polymeric nanoparticle (PNP), and solid lipid nanoparticle (SLN) drug delivery systems.
Figure 2
Figure 2
Schematic representation of unilamellar (A) and multilamellar (B) liposomes. Note: The arrow indicates an enlarged view of the outer layers of multilamellar liposomes.
Figure 3
Figure 3
Hydrophilic polymeric chains network and release the drug for dissolution through the spaces of their mesh.
Figure 4
Figure 4
Schematic representation of lamellar (A), hexagonal (B), and cubic (C) liquid crystal mesophases.
Figure 5
Figure 5
Representation of cyclodextrin, drug, and cyclodextrin complex.
See this image and copyright information in PMC

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