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Meta-Analysis
. 2014:2014:738298.
doi: 10.1155/2014/738298. Epub 2014 Jan 6.

Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis

Bojan Nedovic  1 , Brunella Posteraro  1 , Emanuele Leoncini  1 , Alberto Ruggeri  2 , Rosarita Amore  1 , Maurizio Sanguinetti  2 , Walter Ricciardi  1 , Stefania Boccia  3
Affiliations
Meta-Analysis

Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis

Bojan Nedovic et al. Biomed Res Int. 2014.

Abstract

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in the MBL2 gene, particularly at codon 54 (variant allele B; wild-type allele designated as A), impact upon host susceptibility to Candida infection. This systematic review and meta-analysis were performed to assess the association between MBL2 codon 54 genotype and vulvovaginal candidiasis (VVC) or recurrent VVC (RVVC). Studies were searched in MEDLINE, SCOPUS, and ISI Web of Science until April 2013. Five studies including 704 women (386 cases and 318 controls) were part of the meta-analysis, and pooled ORs were calculated using the random effects model. For subjects with RVVC, ORs of AB versus AA and of BB versus AA were 4.84 (95% CI 2.10-11.15; P for heterogeneity = 0.013; I(2) = 68.6%) and 12.68 (95% CI 3.74-42.92; P for heterogeneity = 0.932, I(2) = 0.0%), respectively. For subjects with VVC, OR of AB versus AA was 2.57 (95% CI 1.29-5.12; P for heterogeneity = 0.897; I (2) = 0.0%). This analysis indicates that heterozygosity for the MBL2 allele B increases significantly the risk for both diseases, suggesting that MBL may influence the women's innate immunity in response to Candida.

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Figures

Figure 1
Figure 1
Flow chart of the study selection.
Figure 2
Figure 2
Meta-analysis of the influence of MBL2 genotype on RVVC susceptibility: AB versus AA and BB versus AA forest plots.
Figure 3
Figure 3
Meta-analysis of the influence of MBL2 genotype on VVC susceptibility: AB versus AA forest plot.
Figure 4
Figure 4
A possible link between the carriage of MBL codon 54 gene polymorphism and the host predisposition to either VVC or RVVC.
See this image and copyright information in PMC

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