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Review
. 2013:2013:193252.
doi: 10.1155/2013/193252. Epub 2013 Sep 19.

Sickle cell disease: new opportunities and challenges in Africa

J Makani  1 , S F Ofori-Acquah  2 , O Nnodu  3 , A Wonkam  4 , K Ohene-Frempong  5
Affiliations
Review

Sickle cell disease: new opportunities and challenges in Africa

J Makani et al. ScientificWorldJournal. 2013.

Abstract

Sickle cell disease (SCD) is one of the most common genetic causes of illness and death in the world. This is a review of SCD in Africa, which bears the highest burden of disease. The first section provides an introduction to the molecular basis of SCD and the pathophysiological mechanism of selected clinical events. The second section discusses the epidemiology of the disease (prevalence, morbidity, and mortality), at global level and within Africa. The third section discusses the laboratory diagnosis and management of SCD, emphasizing strategies that been have proven to be effective in areas with limited resources. Throughout the review, specific activities that require evidence to guide healthcare in Africa, as well as strategic areas for further research, will be highlighted.

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Figures

Figure 1
Figure 1
Developmental control of human haemoglobin (Hb) expression [6].
Figure 2
Figure 2
Selected clinical consequences of SCD.
Figure 3
Figure 3
RFLP of HBB fragment with DdeI. Lane 1: undigested control, Lane 2: HbAA control, Lane 3: HbAS control, and Lane 4: HbSS MW: molecular weight marker.
See this image and copyright information in PMC

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