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Comparative Study
. 2014 Dec;60(6):434-41.
doi: 10.1093/tropej/fmu045. Epub 2014 Aug 21.

Increased morbidity in early childhood among HIV-exposed uninfected children in Uganda is associated with breastfeeding duration

Carina Marquez  1 , Jaffer Okiring  2 , Gabriel Chamie  3 , Theodore D Ruel  4 , Jane Achan  5 , Abel Kakuru  2 , Moses R Kamya  6 , Edwin D Charlebois  7 , Diane V Havlir  3 , Grant Dorsey  8
Affiliations
Comparative Study

Increased morbidity in early childhood among HIV-exposed uninfected children in Uganda is associated with breastfeeding duration

Carina Marquez et al. J Trop Pediatr. 2014 Dec.

Abstract

Human immunodeficiency virus (HIV)-exposed uninfected children (HEU) have an increased risk of morbidity and mortality compared with HIV-unexposed uninfected children (HUU); however, prior studies have not fully accounted for the role of both breastfeeding and age on this association. In this cohort of HEU and HUU in Uganda, non-breastfeeding HEU, from 6-11 months compared with non-breastfeeding HUU had a higher risk of hospitalizations [relative risk (RR): 10.1, 95% confidence interval (CI): 3.70-27.6], severe febrile illness (RR: 3.84, 95% CI: 2.06-7.17), severe diarrhea (RR: 6.37, 95% CI: 2.32-17.4) and severe malnutrition (RR: 18.4, 95% CI: 4.68-72.0). There were no differences between morbidity outcomes between breastfeeding HEU and HUU children, aged 6-11 months. In the 12-24 month age group, the only difference in morbidity outcomes among non-breast feeding children was an increased risk of severe malnutrition for HEU. These data suggest that the increased risk of morbidity among HEU aged 6-11 years is partially explained by early cessation of breastfeeding.

Keywords: Africa; Breastfeeding; HIV; HIV-exposed; Morbidity; Mortality.

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Figures

F<sc>ig</sc>. 1.
Fig. 1.
Study flow diagram. PY accrued from 6 to 24 months were included in this analysis. All PY from children with sickle cell disease or those who HIV sero-converted were excluded from the analysis. For children who withdrew, person-time was included up to study withdrawal date.
F<sc>ig</sc>. 2.
Fig. 2.
Proportion of children breastfeeding (exclusive and partial) from 6 to 24 months, stratified by HIV-exposure status.
See this image and copyright information in PMC

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