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Comment
. 2014 Sep;63(9):2901-3.
doi: 10.2337/db14-0757.

Integrating transcriptome and epigenome: putting together the pieces of the type 2 diabetes pathogenesis puzzle

Swapan Kumar Das  1
Affiliations
Comment

Integrating transcriptome and epigenome: putting together the pieces of the type 2 diabetes pathogenesis puzzle

Swapan Kumar Das. Diabetes. 2014 Sep.
No abstract available

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Figures

Figure 1
Figure 1
A causal model of T2D pathogenesis. Environmental factors (including dietary factors) may modulate the expression of genes by interacting with cellular genetic regulatory architecture or by causing epigenetic modifications of the genome, including DNA methylation. Perturbation of gene expression in tissues important for glucose homeostasis causes derangement of multiple physiological processes and leads to the pathogenesis of T2D. An integrative functional ‘omics paradigm that traces molecular events through layers of biological information is required for solving the puzzle of the etiology of T2D. epiSNP, methylation and other epigenetic regulatory single nucleotide polymorphism (SNP); eSNP, expression regulatory SNP.
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References

    1. Das SK, Sharma NK. Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes 2014;5:97–114 - PMC - PubMed
    1. Barroso I. Genetics of type 2 diabetes. Diabet Med 2005;22:517–535 - PubMed
    1. Ling C, Groop L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 2009;58:2718–2725 - PMC - PubMed
    1. Waki H, Yamauchi T, Kadowaki T. The epigenome and its role in diabetes. Curr Diab Rep 2012;12:673–685 - PubMed
    1. Kaelin WG, Jr, McKnight SL. Influence of metabolism on epigenetics and disease. Cell 2013;153:56–69 - PMC - PubMed

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