Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation

Affiliations

¹ Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
² Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive, # 5043, Hattiesburg, MS 39406-0001, USA.
³ Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
⁴ Department of Chemistry and Biochemistry, Old Dominion University, 4541 Hampton Boulevard, Norfolk, VA 23529-0126, USA.
⁵ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, 21205, USA.
⁶ School of Polymers and High-Performance Materials, The University of Southern Mississippi, 118 College Dive, #5050, Hattiesburg, MS 39406-0076, USA.
⁷ Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, # 5018, Hattiesburg, MS 39406-0001, USA.
⁸ Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: vipan_org@yahoo.com.

PMID: 25147149
DOI: 10.1016/j.ejmech.2014.08.054

Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation

Kewal Kumar et al. Eur J Med Chem. 2014.

. 2014 Oct 30:86:81-6.

doi: 10.1016/j.ejmech.2014.08.054. Epub 2014 Aug 16.

Authors

Affiliations

¹ Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
² Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive, # 5043, Hattiesburg, MS 39406-0001, USA.
³ Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
⁴ Department of Chemistry and Biochemistry, Old Dominion University, 4541 Hampton Boulevard, Norfolk, VA 23529-0126, USA.
⁵ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, 21205, USA.
⁶ School of Polymers and High-Performance Materials, The University of Southern Mississippi, 118 College Dive, #5050, Hattiesburg, MS 39406-0076, USA.
⁷ Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, # 5018, Hattiesburg, MS 39406-0001, USA.
⁸ Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: vipan_org@yahoo.com.

PMID: 25147149
DOI: 10.1016/j.ejmech.2014.08.054

Abstract

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

Keywords: 7-Chloroquinoline thiosemicarbazone; Anti-plasmodial activity; Cytotoxic activity; Gallium(III) complex; Selectivity index.

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Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation

Affiliations

Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources