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Comment
. 2014 Aug 21;41(2):176-8.
doi: 10.1016/j.immuni.2014.07.011.

"Nuts and bolts" of disease tolerance

Miguel P Soares  1
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Free article
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"Nuts and bolts" of disease tolerance

Miguel P Soares. Immunity. .
Free article

Abstract

Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice.

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  • Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
    Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P. Bessede A, et al. Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323. Nature. 2014. PMID: 24930766 Free PMC article.

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