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Review
. 2014 Aug;11 Suppl 4(Suppl 4):S221-6.
doi: 10.1513/AnnalsATS.201401-041PL.

Infections in "noninfectious" lung diseases

Meghan E Fitzpatrick  1 , Sanjay Sethi, Charles L Daley, Prabir Ray, James M Beck, Matthew R Gingo
Affiliations
Review

Infections in "noninfectious" lung diseases

Meghan E Fitzpatrick et al. Ann Am Thorac Soc. 2014 Aug.

Abstract

Many chronic pulmonary diseases, including those that are not primarily infectious in etiology, have some aspects of their pathogenesis that are influenced by infectious organisms. Microorganisms may contribute to chronic lung diseases, either directly (i.e., overt infection) or indirectly, via the amplification of inflammatory pathways that are critical to host defense. As techniques for detecting and characterizing microorganisms have advanced, investigations of both infecting and colonizing organisms have yielded new insights into mechanisms of pulmonary disease. In addition, changes in patterns of infection and microbial resistance have important implications for treatment. Examples of these infectious-pulmonary associations, including Haemophilus influenzae infection and chronic obstructive pulmonary disease, nontuberculous mycobacteria and bronchiectasis, and human immunodeficiency virus and obstructive lung disease, are reviewed.

Keywords: Haemophilus influenza; bronchiectasis; chronic obstructive pulmonary disease; human immunodeficiency virus; nontuberculous mycobacteria.

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Figures

Figure 1.
Figure 1.
Inflammatory cycle of bronchiectasis.
See this image and copyright information in PMC

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