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. 2015 Jan;45(1):221-9.
doi: 10.1007/s10803-014-2211-x.

Screening for autism spectrum disorders in 12-month-old high-risk siblings by parental report

Justin Rowberry  1 , Suzanne Macari, Grace Chen, Daniel Campbell, John M Leventhal, Carol Weitzman, Katarzyna Chawarska
Affiliations

Screening for autism spectrum disorders in 12-month-old high-risk siblings by parental report

Justin Rowberry et al. J Autism Dev Disord. 2015 Jan.

Abstract

This study examines whether parental report of social-communicative and repetitive behaviors at 12 months can be helpful in identifying autism spectrum disorder (ASD) in younger siblings of children with ASD [high-risk (HR)-siblings]. Parents of HR-siblings and infants without a family history of ASD completed the First Year Inventory at 12 months. Developmental outcomes were based on 24- or 36-month assessments. HR-siblings later diagnosed with ASD showed greater impairments in social communication than those with other developmental outcomes based on parental and clinician ratings. Parental report of decline in play and communication and impaired vocal imitation correctly classified a majority of ASD cases with high specificity. These preliminary findings have important implications for the development of early screening instruments for ASD in HR-siblings.

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Conflict of interest statement

Conflict of interest Daniel Cambell, PhD, receives salary and stock options from Amgen Inc. All other authors declare no conflict of interest. The content of this study is solely the responsibility of the authors and does not necessarily represent the views of the National Institute of Child Health and Human Development, National Institutes of Mental Health, Yale Child Study Center, United States Air Force Medical Service or Department of Defense.

Figures

Fig. 1
Fig. 1
Classification tree results. The FYI items used in the model are specified at each branch of the tree, with the values they take for each side of the split. The number of children from each diagnostic group for each leaf is listed below the predicted classification. For example, of the seven children who scored “seldom” or “often” on Q39, 6 are from the ASD group and are classified correctly, and one is from the Non-ASD group and is misclassified. The 64 children who scored “never” on Q39 were further classified based on the results of Q24. Q question, ASD autism spectrum disorder, NA non-ASD
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References

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