Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec;99(12):e257-9.
doi: 10.3324/haematol.2014.110437. Epub 2014 Aug 22.

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions

Florentien E M in 't Hout  1 , Bert A van der Reijden  2 , Davide Monteferrario  1 , Joop H Jansen  2 , Gerwin Huls  3
Affiliations

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions

Florentien E M in 't Hout et al. Haematologica. 2014 Dec.
No abstract available

Keywords: AML; TCF4; treatment.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
TCF4 expression and survival curves in the first cohort. (A) Expression of TCF4 in AML patients (n=525), NBM (n=5) and hCD34+ (n=11). (B) TCF4 expression ranked from lowest to highest expression (n=525). (C) Overall survival (OS) curves for AML patients with available follow-up data (n=518) stratified by TCF4high (n=129) and TCF4low (n=389). (D) Same for event-free survival (EFS). (E) OS curves for 7CF4high AML patients with available follow up and consolidation treatment data (n=129) stratified for conditioning with alloHCT (n=36), autoHCT (n=13) or additional CT (n=80). (F) OS curves for TCF4low AML patients with available follow up and consolidation treatment data (n=386) stratified for conditioning with alloHCT (n=99), autoHCT (n=57) or additional CT (n=212).
See this image and copyright information in PMC

References

    1. Ellenberger T, Fass D, Arnaud M, Harrison SC. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev. 1994;8(8):970–80. - PubMed
    1. Massari ME, Murre C. MINIREVIEW Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms. Mol Cell Biol. 2000;20(2):429–40. - PMC - PubMed
    1. Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122(22):3616–27. - PMC - PubMed
    1. Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059–74. - PMC - PubMed
    1. Makishima H, LaFramboise T, Przychodzen JP, Yoshida K, Ruffalo M, Gómez-Seguí I, et al. Clinical “MUTATOME” Of Myelodysplastic Syndrome; Comparison To Primary Acute Myelogenous Leukemia. ASH Annual Meeting Abstract. Blood. 2013;Abstract 518.

MeSH terms

Substances