Clinical trials of integrative medicine: testing whether magic works?
- PMID: 25150944
- DOI: 10.1016/j.molmed.2014.06.007
Clinical trials of integrative medicine: testing whether magic works?
Abstract
Over the past two decades complementary and alternative medicine treatments relying on dubious science have been embraced by medical academia. Despite low to nonexistent prior probability that testing these treatments in randomized clinical trials (RCTs) will be successful, RCTs of these modalities have proliferated, consistent with the principles of evidence-based medicine, which underemphasize prior plausibility rooted in science. We examine this phenomenon and argue that what is needed is science-based medicine rather than evidence-based medicine.
Keywords: Evidence-based medicine; clinical trials; complementary and alternative medicine; integrative medicine; science-based medicine.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment in
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Making sense of prior probabilities in research.Trends Mol Med. 2014 Nov;20(11):599-600. doi: 10.1016/j.molmed.2014.09.007. Epub 2014 Oct 29. Trends Mol Med. 2014. PMID: 25362626 No abstract available.
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Considering prior plausibility in clinical trials does not mean ignoring scientific evidence.Trends Mol Med. 2014 Nov;20(11):600-1. doi: 10.1016/j.molmed.2014.10.001. Epub 2014 Oct 17. Trends Mol Med. 2014. PMID: 25439966 No abstract available.
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