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Case Reports
. 2014 Aug 14:7:1449-53.
doi: 10.2147/OTT.S66285. eCollection 2014.

Glucagonoma syndrome: a case report with focus on skin disorders

Sheng Fang  1 , Shuang Li  1 , Tao Cai  1
Affiliations
Case Reports

Glucagonoma syndrome: a case report with focus on skin disorders

Sheng Fang et al. Onco Targets Ther. .

Abstract

Glucagonoma syndrome is a rare paraneoplastic phenomenon. Necrolytic migratory erythema is often one of the first presenting symptoms. We report a case of a 55-year-old man with a 2-year history of recalcitrant eruption. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After pancreatectomy, his cutaneous lesions vanished in a few days. Skin symptoms are important, as they are often essential for early diagnosis of glucagonoma syndrome and may prevent metastatic disease; hence, in this report, we focus on skin disorders in glucagonoma syndrome.

Keywords: necrolytic migratory erythema.

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Figures

Figure 1
Figure 1
Necrolytic migratory erythema with erosion and crust formation. Notes: (A) Face; (B) legs; (C) perianal region.
Figure 2
Figure 2
Skin biopsy in necrolytic migratory erythema showing a large zone of necrolysis in the upper epidermis (arrow). Notes: Hematoxylin and eosin staining; magnification ×40.
Figure 3
Figure 3
Computed tomography scan of the abdomen of the patient showing a large tumor in the tail of the pancreas.
Figure 4
Figure 4
Resolution of cutaneous lesions 1 week after surgery. Notes: (A) Face; (B) legs; (C) perianal region.
See this image and copyright information in PMC

References

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