doi: 10.1002/anie.201405647.
Epub 2014 Aug 26.
Aldehyde-assisted ruthenium(II)-catalyzed C-H oxygenations
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- PMID: 25154310
- DOI: 10.1002/anie.201405647
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Aldehyde-assisted ruthenium(II)-catalyzed C-H oxygenations
Angew Chem Int Ed Engl.
.
Abstract
Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.
Keywords: CH activation; aldehydes; chemoselectivity; oxygenation; ruthenium.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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