Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Oct 1;104(1):226-7.
doi: 10.1093/cvr/cvu198. Epub 2014 Aug 25.

Cardiac remodelling during pregnancy: whither the guinea pig?

Affiliations
Comment

Cardiac remodelling during pregnancy: whither the guinea pig?

Michael J Taggart et al. Cardiovasc Res. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Guinea pig pregnancy induces increased expression of cardiac ventricular ADBR1, INSR, and S1P1R. RNA samples were isolated from left ventricles of non-pregnant and late pregnant (Day 68) guinea pig hearts (n = 6); gene-specific quantitative PCR probes were designed for (A) ADRB1, (B) INSR, and (C) S1P1R by alignment with the Cavia porcellus genome and amplicons detected by SYBR green quantification. Results are expressed as mean ±SEM fold change relative to a control RNA sample. Student’s t-test was used to test significance, *P < 0.05.

Comment on

  • Pregnancy as a cardiac stress model.
    Chung E, Leinwand LA. Chung E, et al. Cardiovasc Res. 2014 Mar 15;101(4):561-70. doi: 10.1093/cvr/cvu013. Epub 2014 Jan 20. Cardiovasc Res. 2014. PMID: 24448313 Free PMC article. Review.

References

    1. Chung E, Leinwand LA. Pregnancy as a cardiac stress model. Cardiovasc Res. 2014;101:561–570. - PMC - PubMed
    1. Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198–205. - PubMed
    1. Mitchell BF, Taggart MJ. Are animal models relevant to key aspects of human parturition. Am J Physiol. 2009;297:R525–R545. - PubMed
    1. Hart MV, Hosenpud JD, Hohimer AR, Morton MJ. Hemodynamics during pregnancy and sex steroid administration in guinea pigs. Am J Physiol. 1985;249:R179–R185. - PubMed
    1. Flicek P, Amode MR, Barrell D, Beal K, Billis K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fitzgerald S, Gil L, Girón CG, Gordon L, Hourlier T, Hunt S, Johnson N, Juettemann T, Kähäri AK, Keenan S, Kulesha E, Martin FJ, Maurel T, McLaren WM, Murphy DN, Nag R, Overduin B, Pignatelli M, Pritchard B, Pritchard E, Riat HS, Ruffier M, Sheppard D, Taylor K, Thormann A, Trevanion SJ, Vullo A, Wilder SP, Wilson M, Zadissa A, Aken BL, Birney E, Cunningham F, Harrow J, Herrero J, Hubbard TJ, Kinsella R, Muffato M, Parker A, Spudich G, Yates A, Zerbino DR, Searle SM. Ensembl 2014. Nucleic Acids Res. 2014;42:D749–D755. - PMC - PubMed