Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Sep;41(3):619-32.
doi: 10.1016/j.clp.2014.05.010. Epub 2014 Jul 18.

Renal teratogens

Thomas M Morgan  1 , Deborah P Jones  2 , William O Cooper  3
Affiliations
Review

Renal teratogens

Thomas M Morgan et al. Clin Perinatol. 2014 Sep.

Abstract

In utero exposure to certain drugs early in pregnancy may adversely affect nephrogenesis. Exposure to drugs later in pregnancy may affect the renin-angiotensin system, which could have an impact on fetal or neonatal renal function. Reduction in nephron number and renal function could have adverse consequences for the child several years later. Data are limited on the information needed to guide decisions for patients and providers regarding the use of certain drugs in pregnancy. The study of drug nephroteratogenicity has not been systematized, a large, standardized, global approach is needed to evaluate the renal risks of in utero drug exposures.

Keywords: Drug safety; Kidney development; Pregnancy; Teratogens.

PubMed Disclaimer