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. 2015 Jan 1;121(1):102-12.
doi: 10.1002/cncr.29015. Epub 2014 Aug 25.

Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010

Haley R Gittleman  1 , Quinn T Ostrom, Chaturia D Rouse, Jacqueline A Dowling, Peter M de Blank, Carol A Kruchko, J Bradley Elder, Steven S Rosenfeld, Warren R Selman, Andrew E Sloan, Jill S Barnholtz-Sloan
Affiliations
Free PMC article

Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010

Haley R Gittleman et al. Cancer. .
Free PMC article

Abstract

Background: Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of cancer in the United States is declining. Although central nervous system tumors (CNST) are rare, they contribute disproportionately to mortality and morbidity. In this analysis, the authors examined trends in the incidence of the most common cancers and CNST between 2000 and 2010.

Methods: The current analysis used data from the United States Cancer Statistics publication and the Central Brain Tumor Registry of the United States. Age-adjusted IR per 100,000 population with 95% confidence intervals and the annual percent change (APC) with 95% confidence intervals were calculated for selected common cancers and CNST overall and by age, sex, race/ethnicity, selected histologies, and malignancy status.

Results: In adults, there were significant decreases in colon (2000-2010: APC, -3.1), breast (2000-2010: APC, -0.8), lung (2000-2010: APC, -1.1), and prostate (2000-2010: APC, -2.4) cancer as well as malignant CNST (2008-2010: APC, -3.1), but a significant increase was noted in nonmalignant CNST (2004-2010: APC, 2.7). In adolescents, there were significant increases in malignant CNST (2000-2008: APC, 1.0) and nonmalignant CNST (2004-2010: APC, 3.9). In children, there were significant increases in acute lymphocytic leukemia (2000-2010: APC, 1.0), non-Hodgkin lymphoma (2000-2010: APC, 0.6), and malignant CNST (2000-2010: APC, 0.6).

Conclusions: Surveillance of IR trends is an important way to measure the changing public health and economic burden of cancer. In the current study, there were significant decreases noted in the incidence of adult cancer, whereas adolescent and childhood cancer IR were either stable or increasing.

Keywords: Central Brain Tumor Registry of the United States (CBTRUS); United States Cancer Statistics (USCS); annual percent change (APC); central nervous system tumors; incidence rates; time trends.

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Figures

Figure 1
Figure 1
Incidence rates from 2000 through 2010 are shown for selected cancers in adults, adolescents, and children, based on the United States Cancer Statistics (USCS) publication for 2000 to 2010 and the Central Brain Tumor Registry of the United States (CBTRUS) for 2000 through 2010. Overall age-adjusted incidence rates per 100,000 population from 2000 through 2010 are presented for selected common cancers and selected brain and central nervous system (CNS) histologies in adults, adolescents, and children.
Figure 2
Figure 2
Malignant incidence time trends for selected cancers in (A) adults, (B) adolescents, and (C) children are shown based on the United States Cancer Statistics (USCS) publication for 2000 to 2010 and the Central Brain Tumor Registry of the United States (CBTRUS) for 2000 through 2010. Age-adjusted incidence rates per 100,000 population were plotted annually from 2000 through 2010 for selected common cancers in adults, adolescents, and children. Each time trend is accompanied by its respective Joinpoint trend line(s). CNS, central nervous system.
Figure 3
Figure 3
Incidence time trends for selected nonmalignant brain and central nervous system (CNS) histologies are shown in (A) adults, (B) adolescents, and (C) children based on the Central Brain Tumor Registry of the United States (CBTRUS) for 2004 through 2010. Age-adjusted incidence rates per 100,000 population were plotted annually from 2004 through 2010 for selected nonmalignant brain and CNS histologies in adults, adolescents, and children. Each time trend is accompanied by its respective Joinpoint trend line(s).
Figure 4
Figure 4
Incidence time trends for selected malignant brain and central nervous system (CNS) histologies are shown in (A) adults, (B) adolescents, and (C) children based on the Central Brain Tumor Registry of the United States (CBTRUS) for 2000 through 2010. Age-adjusted incidence rates per 100,000 population were plotted annually from 2000 through 2010 for selected malignant brain and CNS histologies in adults, adolescents, and children. Each time trend is accompanied by its respective Joinpoint trend line(s).
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