Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Aug;38(8):2160-3.
doi: 10.1111/acer.12484.

Commentary: catching a conserved mechanism of ethanol teratogenicity

C Ben Lovely  1 , Johann K Eberhart
Affiliations
Comment

Commentary: catching a conserved mechanism of ethanol teratogenicity

C Ben Lovely et al. Alcohol Clin Exp Res. 2014 Aug.

Abstract

Background: Due to its profound impact on human development, ethanol (EtOH) teratogenicity is a field of intense study. The complexity of variables that influence the outcomes of embryonic or prenatal EtOH exposure compels the use of animal models in which these variables can be isolated.

Methods: Numerous model systems have been used in these studies. The zebrafish is a powerful model system, which has seen a recent increase in usage for EtOH studies.

Results: Those using zebrafish for alcohol studies often face 2 questions: (i) How physiologically relevant are the doses of EtOH administered to zebrafish embryos? and (ii) Will the mechanisms of EtOH teratogenesis be conserved to other model systems and human?

Conclusions: The current article by Flentke and colleagues () helps to shed important light on these questions and clearly demonstrates that the zebrafish will be a valuable model system with which to understand EtOH teratogenicity.

Keywords: Fetal Alcohol Spectrum Disorder; Zebrafish.

PubMed Disclaimer

Comment on

References

    1. Adalsteinsson E, Sullivan EV, Mayer D, Pfefferbaum A. In vivo quantification of ethanol kinetics in rat brain. Neuropsychopharmacology. 2006;31(12):2683–91. - PubMed
    1. Ahlgren SC, Thakur V, Bronner-Fraser M. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc Natl Acad Sci U S A. 2002;99(16):10476–81. - PMC - PubMed
    1. Ali S, Champagne DL, Alia A, Richardson MK. Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience. PLoS One. 2011;6(5):e20037. - PMC - PubMed
    1. Auer TO, Del Bene F. CRISPR/Cas9 and TALEN-mediated knock-in approaches in zebrafish. Methods 2014 - PubMed
    1. Bedell VM, Wang Y, Campbell JM, Poshusta TL, Starker CG, Krug RG, 2nd, Tan W, Penheiter SG, Ma AC, Leung AY, Fahrenkrug SC, Carlson DF, Voytas DF, Clark KJ, Essner JJ, Ekker SC. In vivo genome editing using a high-efficiency TALEN system. Nature. 2012;491(7422):114–8. - PMC - PubMed

Publication types

MeSH terms