Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Sep;17(9):1138-40.
doi: 10.1038/nn.3792.

The epigenetic landscape of Alzheimer's disease

Jenny Lord  1 , Carlos Cruchaga  2
Affiliations
Comment

The epigenetic landscape of Alzheimer's disease

Jenny Lord et al. Nat Neurosci. 2014 Sep.

Abstract

Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease. These studies also suggest that epigenetic changes contribute more to Alzheimer’s disease than expected.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Loci showing consistent methylation changes in both studies
Four CpG sites close to ANK1, RHBDF2, RPL13, C10orf54–CDH23 were associated with Alzheimer’s disease pathology. Three of them (ANK1, RPL13 and RHBDF2) are biologically linked to PTK2B, a known AD gene. The fourth gene (CDH23) is involved in neuronal differentiation.
See this image and copyright information in PMC

Comment on

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
    De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, Chai HS, Younkin C, Younkin SG, Zou F, Szyf M, Epstein CB, Schneider JA, Bernstein BE, Meissner A, Ertekin-Taner N, Chibnik LB, Kellis M, Mill J, Bennett DA. De Jager PL, et al. Nat Neurosci. 2014 Sep;17(9):1156-63. doi: 10.1038/nn.3786. Epub 2014 Aug 17. Nat Neurosci. 2014. PMID: 25129075 Free PMC article.
  • Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.
    Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J. Lunnon K, et al. Nat Neurosci. 2014 Sep;17(9):1164-70. doi: 10.1038/nn.3782. Epub 2014 Aug 17. Nat Neurosci. 2014. PMID: 25129077 Free PMC article.

References

    1. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer’s disease. Alzheimers & Dementia. 2007;3:186–191. - PubMed
    1. Lambert JC, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet. 2013 doi: 10.1038/ng.2802. - DOI - PMC - PubMed
    1. Ertekin-Taner N. Genetics of Alzheimer disease in the pre- and post-GWAS era. Alzheimers Res Ther. 2010;2:3. doi:alzrt26 [pii] 10.1186/alzrt26. - PMC - PubMed
    1. Lunnon K, Smith R, Volta M, Troakes C, Mill J. Cross-tissue methylomic profiling in Alzheimer’s disease implicates a role for cortex-specific deregulation of ANK1 in neuropathology. Nature Neuroscience. 2014 - PMC - PubMed
    1. DeJager P, et al. Alzheimer’s disease pathology is associated with early alterations in brain DNA 2 methylation at ANK1, BIN1 and other loci. Nature Neuroscience. 2014 - PMC - PubMed

MeSH terms