Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Oct;8(7):1163-8.
doi: 10.1016/j.molonc.2014.07.021. Epub 2014 Aug 12.

Molecular pathology - the value of an integrative approach

Manuel Salto-Tellez  1 , Jacqueline A James  2 , Peter W Hamilton  3
Affiliations
Review

Molecular pathology - the value of an integrative approach

Manuel Salto-Tellez et al. Mol Oncol. 2014 Oct.

Abstract

Molecular Pathology (MP) is at the heart of modern diagnostics and translational research, but the controversy on how MP is best developed has not abated. The lack of a proper model or trained pathologists to support the diagnostic and research missions makes MP a rare commodity overall. Here we analyse the scientific and technology areas, in research and diagnostics, which are encompassed by MP of solid tumours; we highlight the broad overlap of technologies and analytical capabilities in tissue research and diagnostics; and we describe an integrated model that rationalizes technical know-how and pathology talent for both. The model is based on a single, accredited laboratory providing a single standard of high-quality for biomarker discovery, biomarker validation and molecular diagnostics.

Keywords: Molecular diagnostics; Molecular pathology; Translational research.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pipeline to deliver basic science discoveries into diagnostic and therapeutic end‐points.
Figure 2
Figure 2
The integrated puzzle of pathology activities and technologies.
See this image and copyright information in PMC

References

    1. Bai, Y. , Cheng, H. , Bordeaux, J. , Neumeister, V. , Kumar, S. , Rimm, D.L. , Stern, D.F. , 2013. Comparison of HER2 and phospho-HER2 expression between biopsy and resected breast cancer specimens using a quantitative assessment method. PLoS One. 8, (11) e79901 - PMC - PubMed
    1. Chan, J.Y. , Salto-Tellez, M. , 2012. Opinion: molecular gestalt and modern pathology. Adv. Anat. Pathol. 19, (6) 425–426. - PubMed
    1. Dietel, M. , Jöhrens, K. , Laffert, M. , Hummel, M. , Bläker, H. , Müller, B.M. , Lehmann, A. , Denkert, C. , Heppner, F.L. , Koch, A. , Sers, C. , Anagnostopoulos, I. , 2013. Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance. Cancer Gene Ther. 20, (4) 211–221. - PubMed
    1. Dorsey, D.B. , 1989. Evolving concepts of quality in laboratory practice. A historical overview of quality assurance in clinical laboratories. Arch. Pathol. Lab. Med. 113, (12) 1329–1334. - PubMed
    1. Drucker, E. , Krapfenbauer, K. , 2013. Pitfalls and limitations in translation from biomarker discovery to clinical utility in predictive and personalised medicine. E.P.M.A. J. 4, (1) 7 - PMC - PubMed

Publication types

Substances

LinkOut - more resources