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Comment
. 2015 May;61(5):1766-7.
doi: 10.1002/hep.27400. Epub 2015 Mar 23.

Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor

Saleh Rachidi  1 , Shaoli Sun, Zihai Li
Affiliations
Comment

Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor

Saleh Rachidi et al. Hepatology. 2015 May.
No abstract available

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Figures

Figure 1
Figure 1. Alb-cre-gp96flox/flox mice (KO) have increased liver carcinogenesis from residual gp96+ hepatocytes
(A) Representative images of WT and KO tumors. (B) Quantification of liver tumors from WT and KO mice 62 weeks post DENA injection.
See this image and copyright information in PMC

Comment in

  • Reply: To PMID 24027047.
    Lee AS, Chen WT. Lee AS, et al. Hepatology. 2015 May;61(5):1767-8. doi: 10.1002/hep.27405. Epub 2014 Dec 24. Hepatology. 2015. PMID: 25176452 Free PMC article. No abstract available.

Comment on

References

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    1. Staron M, Yang Y, Liu B, Li J, Shen Y, Zuniga-Pflucker JC, Aguila HL, et al. gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood. 2010;115:2380–2390. - PMC - PubMed
    1. Chen WT, Zhu G, Pfaffenbach K, Kanel G, Stiles B, Lee AS. GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2013 - PMC - PubMed

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