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. 2015 Dec;26(12):1402-6.
doi: 10.1111/clr.12465. Epub 2014 Aug 28.

Bone neo-formation and mineral degradation of 4Bone.(®) Part II: histological and histomorphometric analysis in critical size defects in rabbits

José Luis Calvo-Guirado  1 , Jose E Maté-Sánchez  1 , Rafael A Delgado-Ruiz  2 , Georgios E Romanos  2 , Piedad De Aza-Moya  3 , Pablo Velázquez  3
Affiliations

Bone neo-formation and mineral degradation of 4Bone.(®) Part II: histological and histomorphometric analysis in critical size defects in rabbits

José Luis Calvo-Guirado et al. Clin Oral Implants Res. 2015 Dec.

Retraction in

  • Retraction.
    [No authors listed] [No authors listed] Clin Oral Implants Res. 2018 Jul;29(7):813. doi: 10.1111/clr.13091. Epub 2018 May 12. Clin Oral Implants Res. 2018. PMID: 30240025

Abstract

Objective: To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic.

Materials and method: In this study, porous HA/βTCP (4Bone(®) ) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic's components HA/βTCP was 60/40 (in wt%).

Results: The 4Bone(®) showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52).

Conclusions: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

Keywords: HA/βTCP; histological analysis; histomorphometric analysis; resorption; synthetic biomaterial.

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