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. 2014 Aug 28:7:578.
doi: 10.1186/1756-0500-7-578.

Prevalence of national treatment algorithm defined smear positive pulmonary tuberculosis in HIV positive patients in Brazzaville, Republic of Congo

Laure Stella Ghoma Linguissi, Pembe Issamou Mayengue, Anissa Sidibé, Jeannhey C Vouvoungui, Mitawa Missontsa, Igor Kevin Madzou-Laboum, Gaston Bango Essassa, Sunny Oyakhirome, Matthias Frank, Veronique Penlap, Francine Ntoumi  1
Affiliations

Prevalence of national treatment algorithm defined smear positive pulmonary tuberculosis in HIV positive patients in Brazzaville, Republic of Congo

Laure Stella Ghoma Linguissi et al. BMC Res Notes. .

Abstract

Background: In the Republic in Congo, the national algorithm for the diagnosis of pulmonary tuberculosis (TB) relies on Ziehl-Neelsen (ZN) sputum smear microscopy, chest X-ray radiography (CXR) and clinical symptoms. Microscopy positive pulmonary TB (MPT+) is defined as symptoms of TB and a positive ZN smear. Microscopy negative pulmonary TB (MPT-) is defined as symptoms of TB, a negative ZN smear but CXR changes consistent with TB. The present cross-sectional study was designed to determine the prevalence of positive and negative MPT individuals among HIV positive and HIV negative individuals presenting to an ambulatory TB treatment center (CTA) in Brazzaville.

Methods: All study participants underwent a physical examination, chest radiography and three ZN sputum smear examinations and HIV testing. Viral load and CD4 counts were determined for HIV positive individuals.

Results: 775 individuals presented with symptoms of TB. 425 individuals accepted the voluntary HIV test. 133 (31.3%) were HIV positive (HIV+) and 292 (68.7%) were HIV negative (HIV-). Of the 292 HIV- individuals 167 (57%) were classified as positive MPT and 125 (43%) as negative MPT. Of the 133 HIV positive individuals 39 (29%) were classified as MPT + and 94 (71%) as MPT-.

Conclusion: Our study shows that the prevalence of positive MPT individuals is lower among HIV positive individuals compared to HIV negative individuals in agreement to reports from other countries. The data suggest that a substantial number of HIV positive pulmonary TB cases are not detected by the national algorithm and highlight the need for new diagnostic tests in this population.

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Figures

Figure 1
Figure 1
National algorithm for the diagnosis of pulmonary TB.
Figure 2
Figure 2
Sputum smear microscopy, HIV test and chest X-Ray results for the study participants. + means Patients with smear positive or smear negative microscopy CXR means Chest X-ray.
See this image and copyright information in PMC

References

    1. Wood R, Lawn SD, Caldwell J, Kaplan R, Middelkoop K, Bekker L-G, Bekker L-G. Burden of New and recurrent tuberculosis in a major south African city stratified by Age and HIV-status. PLoS One. 2011;6(10):e25098. doi: 10.1371/journal.pone.0025098. - DOI - PMC - PubMed
    1. World Health Organization . WHO Report. 2011. Global tuberculosis control report.
    1. UNAIDS . Report on the global AIDS epidemic. 2012.
    1. Cain KP, McCarthy KD, Heilig CM, Monkongdee P, Tasaneeyapan T, Kanara N, Kimerling ME, Chheng P, Thai S, Sar B, Phanuphak P, Teeratakulpisarn N, Phanuphak N, Nguyen HD, Hoang TQ, Le HT, Varma JK. An algorithm for tuberculosis screening and diagnosis in people with HIV. N Engl J Med. 2010;362(8):707–716. doi: 10.1056/NEJMoa0907488. - DOI - PubMed
    1. Granich R, Akolo C, Gunneberg C, Getahun H, Williams P, Williams B. Prevention of tuberculosis in people living with HIV. Clin Infect Dis. 2010;50(Supplement 3):S215–S222. doi: 10.1086/651494. - DOI - PubMed

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