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Comparative Study
. 1989 Nov-Dec;52(6):58-61.

[The effect of pharmacologic blockade of serotonin receptors (S2) on arterial pressure in rats with 2 forms of hereditary arterial hypertension]

[Article in Russian]
N K Popova, A I Piianzin, A L Markel'
  • PMID: 2516487
Comparative Study

[The effect of pharmacologic blockade of serotonin receptors (S2) on arterial pressure in rats with 2 forms of hereditary arterial hypertension]

[Article in Russian]
N K Popova et al. Farmakol Toksikol. 1989 Nov-Dec.

Abstract

The influence of blockade of serotonin S2 receptors with ketanserin was studied in two strains of rats with inherited arterial hypertension: spontaneously hypertensive rats (SHR strain) and rats with inherited stress-induced arterial hypertension (ISIAH strain). It was found that peripheral injection of ketanserin produced a greater decrease of arterial blood pressure than i.c.v. administration. ISIAH rats were more sensitive to the hypotensive effect of ketanserin when compared to normotensive Wistar or SHR rats.

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