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. 2015 Jan 1;60(1):e1-3.
doi: 10.1093/cid/ciu681. Epub 2014 Aug 27.

Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection

Anastasia P Litvintseva  1 , Nicola Marsden-Haug  2 , Steven Hurst  1 , Heather Hill  3 , Lalitha Gade  1 , Elizabeth M Driebe  4 , Cindy Ralston  3 , Chandler Roe  4 , Bridget M Barker  4 , Marcia Goldoft  2 , Paul Keim  4 , Ron Wohrle  2 , George R Thompson 3rd  5 , David M Engelthaler  4 , Mary E Brandt  1 , Tom Chiller  1
Affiliations

Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection

Anastasia P Litvintseva et al. Clin Infect Dis. .

Abstract

We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients.

Keywords: Coccidioides; WGS typing; soil detection; valley fever.

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Figures

Figure 1.
Figure 1.
Phylogenetic analysis of genomes of isolates from the patient (Washington 1), Washington environment (CDC 202, CDC 205, CDC 211, and CDC 212), and unrelated Coccidioides immitis strains (n = 6) from California visualized by maximum parsimony method and rooted at midpoint. Abbreviation: CDC, Centers for Disease Control and Prevention.
See this image and copyright information in PMC

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