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Comment
. 2015 Feb 15;211(4):664-5.
doi: 10.1093/infdis/jiu489. Epub 2014 Aug 26.

Reply to eisenhut

Maximilian Muenchhoff  1 , Philip Goulder  1
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Reply to eisenhut

Maximilian Muenchhoff et al. J Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Generalized model of sexual dimorphisms in nonspecific vaccine effects. Immunization activates innate immune pathways through pattern recognition receptors (PRRs). Epigenetic programming of innate immune genes persistently enhances expression of proinflammatory cytokines. This effect of trained immunity is stronger in females because of their bias toward proinflammatory immune responses. Proinflammatory cytokines induce the expression of innate immune genes, such as those encoding PRRs, in a positive feedback loop. Abbreviations: NLRs, NOD-like receptors; TLRs, Toll-like receptors.
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References

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