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Meta-Analysis
. 2014:2014:265274.
doi: 10.1155/2014/265274. Epub 2014 Jul 7.

Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis

Khaled Lasram  1 , Nizar Ben Halim  1 , Sana Hsouna  1 , Rym Kefi  1 , Imen Arfa  1 , Welid Ghazouani  1 , Henda Jamoussi  2 , Houda Benrahma  3 , Najla Kharrat  4 , Ahmed Rebai  4 , Slim Ben Ammar  5 , Sonia Bahri  5 , Abdelhamid Barakat  3 , Abdelmajid Abid  2 , Sonia Abdelhak  1
Affiliations
Meta-Analysis

Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis

Khaled Lasram et al. Biomed Res Int. 2014.

Abstract

Aims: Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations.

Methods: We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.).

Results: A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14-2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15-1.46, and P < 10(-3) and OR = 1.33, 95% CI = 1.13-1.56, and P = 0.001, resp.).

Conclusion: Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.

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Figures

Figure 1
Figure 1
Meta-analysis of the association between KCNJ11 E23K and T2DM in Tunisian population. Forest plot of allelic odds ratio (OR). The area of the squares reflects the study specific weight. The diamond shows the summary fixed-effects odds ratio estimate from 2 studies.
Figure 2
Figure 2
Meta-analysis of the association between KCNJ11 E23K and T2DM in Arab population. Forest plot of allelic odds ratio (OR) under the random-effects model. The area of the squares reflects the study specific weight. The diamond shows the summary odds ratio estimate from 5 studies.
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