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Review
. 2014:2014:303782.
doi: 10.1155/2014/303782. Epub 2014 Aug 5.

Congenital defects in neutrophil dynamics

Marton Keszei  1 , Lisa S Westerberg  1
Affiliations
Review

Congenital defects in neutrophil dynamics

Marton Keszei et al. J Immunol Res. 2014.

Abstract

Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50-70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion.

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Figures

Figure 1
Figure 1
Neutrophil development, migration, and function. Diseases described in the review are indicated where they are believed to act.
Figure 2
Figure 2
Neutrophil polarity during migration. The role of the cell cytoskeleton and the proteins that regulate cell polarity is indicated.
See this image and copyright information in PMC

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