Immunity, inflammation, and vaccines for Helicobacter pylori
- PMID: 25167941
- DOI: 10.1111/hel.12156
Immunity, inflammation, and vaccines for Helicobacter pylori
Abstract
Helicobacter pylori colonizes mucosa, activates Toll-like and Nod-like receptors, and usually elicits a gastric T-helper 1/17 (Th1/Th17) type of immune response. Among several bacterial factors, the secreted peptidyl prolyl cis, trans-isomerase of H. pylori represents a key factor driving Th17 inflammation. A complex and fascinating balance between H. pylori and host factors takes part in the gastric niche and is responsible for the chronicity of the infection. Novel insights into the innate and adaptive responses against H. pylori, dealing with gastric epithelial cells, cytokines, and immune evasion have been elucidated over the past year and are discussed for the development of an effective vaccine.
© 2014 John Wiley & Sons Ltd.
Similar articles
-
Helicobacter pylori inflammation, immunity, and vaccines.Helicobacter. 2007 Oct;12 Suppl 1:15-9. doi: 10.1111/j.1523-5378.2007.00530.x. Helicobacter. 2007. PMID: 17727455 Review.
-
Helicobacter pylori immunology and vaccines.Helicobacter. 2008 Oct;13 Suppl 1:18-22. doi: 10.1111/j.1523-5378.2008.00636.x. Helicobacter. 2008. PMID: 18783517 Review.
-
Inflammation, immunity, vaccines for Helicobacter pylori infection.Helicobacter. 2013 Sep;18 Suppl 1:18-23. doi: 10.1111/hel.12073. Helicobacter. 2013. PMID: 24011240 Review.
-
Inflammation, immunity, and vaccines for Helicobacter pylori.Helicobacter. 2009 Sep;14 Suppl 1:21-8. doi: 10.1111/j.1523-5378.2009.00698.x. Helicobacter. 2009. PMID: 19712164 Review.
-
Inflammation, immunity, and vaccine development for Helicobacter pylori.Helicobacter. 2011 Sep;16 Suppl 1:26-32. doi: 10.1111/j.1523-5378.2011.00877.x. Helicobacter. 2011. PMID: 21896082 Review.
Cited by
-
Nickel and GTP Modulate Helicobacter pylori UreG Structural Flexibility.Biomolecules. 2020 Jul 16;10(7):1062. doi: 10.3390/biom10071062. Biomolecules. 2020. PMID: 32708696 Free PMC article.
-
Immunological markers and Helicobacter pylori in patients with stomach cancer: Expression and correlation.Biomed Rep. 2020 May;12(5):233-243. doi: 10.3892/br.2020.1285. Epub 2020 Mar 4. Biomed Rep. 2020. PMID: 32257186 Free PMC article.
-
Association of TLR4 and Treg in Helicobacter pylori Colonization and Inflammation in Mice.PLoS One. 2016 Feb 22;11(2):e0149629. doi: 10.1371/journal.pone.0149629. eCollection 2016. PLoS One. 2016. PMID: 26901645 Free PMC article.
-
Chinese Helicobacter pylori vaccine: Solution for an old challenge?World J Gastrointest Pharmacol Ther. 2016 Aug 6;7(3):412-5. doi: 10.4292/wjgpt.v7.i3.412. World J Gastrointest Pharmacol Ther. 2016. PMID: 27602242 Free PMC article. Review.
-
Protection Against Helicobacter pylori Infection in BALB/c Mouse Model by Oral Administration of Multivalent Epitope-Based Vaccine of Cholera Toxin B Subunit-HUUC.Front Immunol. 2018 May 8;9:1003. doi: 10.3389/fimmu.2018.01003. eCollection 2018. Front Immunol. 2018. PMID: 29867978 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous