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. 2015 Jan;4(1):51-9.
doi: 10.2217/cer.14.48.

Impact of once-daily extended-release quetiapine fumarate on hospitalization length in patients with acute bipolar mania

Machaon Bonafede  1 , Julie C Locklear, Peter Wahlqvist, Liberty Fajutrao, Johan Szamosi, Katy Pan, Hans Eriksson
Affiliations
Free article

Impact of once-daily extended-release quetiapine fumarate on hospitalization length in patients with acute bipolar mania

Machaon Bonafede et al. J Comp Eff Res. 2015 Jan.
Free article

Abstract

Aims: Evaluate the impact of quetiapine extended release (XR) versus quetiapine immediate release (IR) on hospitalization length in acute bipolar mania using Truven Health Analytics MarketScan Hospital Drug Database.

Patients & methods: Generalized linear model analyses were used, adjusting for patient and hospital characteristics.

Results: Using data from 3088 discharges, quetiapine XR reduced hospitalization length by 6.7% versus quetiapine IR (p = 0.11; no statistically significant differences between groups), corresponding to 0.6 fewer days in hospital. Excluding the outlier, quetiapine XR significantly reduced hospitalization length by 9.6% versus quetiapine IR (p = 0.02), corresponding to 0.9 days.

Conclusion: Inpatient use of quetiapine XR in acute bipolar mania may be associated with reduced hospitalization length (7-10%), possibly owing to the faster titration schedule versus quetiapine IR.

Keywords: acute bipolar mania; cost; hospitalization; quetiapine XR.

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