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Review
. 2014 May 13;6(5):87-98.
doi: 10.5539/gjhs.v6n5p87.

Biochemical and pathological studies on peroxidases -an updated review

Amjad A Khan  1 , Arshad H Rahmani, Yousef H Aldebasi, Salah M Aly
Affiliations
Review

Biochemical and pathological studies on peroxidases -an updated review

Amjad A Khan et al. Glob J Health Sci. .

Abstract

Peroxidases represent a family of isoenzymes actively involved in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases. Different types of peroxidases have organ, tissues, cellular and sub-cellular level of specificities in their function. Different diseases lead to varied expressions of peroxidases based on several mechanisms proposed. Several researches are going on to understand its deficiency, over-expression and malfunction in relation with different diseases. Some common diseases of mankind like cancer, cardiovascular diseases and diabetes directly or indirectly involve the role of peroxidases. So the status of peroxidase levels may also function as a marker of different diseases. Although many types of diseases in human beings have a strong correlation with tissue specific peroxidases, the clear role of these oxido-reductases is not yet fully understood. Here we are focusing on the role of peroxidases in relations with different diseases occurring due to oxidative stress.

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Figures

Figure 1
Figure 1
Fundamental steps of the catalytic cycle of heme peroxidases. Free radicals O2•− (hydroxyl radical) is generated by the action of xanthine oxidase (XO) or NADPH oxidase and H2O2 is formed from these free radicals by superoxide dismutase (SOD)
Figure 2
Figure 2
Selenocysteine containing Glutathione peroxidase biosynthesis model
See this image and copyright information in PMC

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