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Review
. 2014 Sep 2;64(9):938-45.
doi: 10.1016/j.jacc.2014.06.1167.

Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities

Pimprapa Vejpongsa  1 , Edward T H Yeh  2
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Free article
Review

Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities

Pimprapa Vejpongsa et al. J Am Coll Cardiol. .
Free article

Abstract

Anthracycline compounds are major culprits in chemotherapy-induced cardiotoxicity, which is the chief limiting factor in delivering optimal chemotherapy to cancer patients. Although extensive efforts have been devoted to identifying strategies to prevent anthracycline-induced cardiotoxicity, there is little consensus regarding the best approach. Recent advances in basic mechanisms of anthracycline-induced cardiotoxicity provided a unified theory to explain the old reactive-oxygen species hypothesis and identified topoisomerase 2β as the primary molecular target for cardioprotection. This review outlines current strategies for primary and secondary prevention of anthracycline-induced cardiotoxicity resulting from newly recognized molecular mechanisms and identifies knowledge gaps requiring further investigation.

Keywords: cancer; cardiomyopathy; cardioprotection; chemotherapy; doxorubicin; heart failure.

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