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. 2014 Aug 28;2(4):e00849-14.
doi: 10.1128/genomeA.00849-14.

Novel replication-competent circular DNA molecules from healthy cattle serum and milk and multiple sclerosis-affected human brain tissue

Corinna Whitley  1 , Karin Gunst  1 , Hermann Müller  2 , Mathis Funk  1 , Harald Zur Hausen  1 , Ethel-Michele de Villiers  3
Affiliations

Novel replication-competent circular DNA molecules from healthy cattle serum and milk and multiple sclerosis-affected human brain tissue

Corinna Whitley et al. Genome Announc. .

Abstract

Epidemiological data point to the involvement of a cow milk factor in the etiology of multiple sclerosis (MS). Eleven circular DNA molecules closely related to transmissible spongiform encephalopathy (TSE)-associated isolate Sphinx 1.76 were isolated from healthy cattle serum, cow milk, and serum and brain tissue from MS patients.

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