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Comment
. 2014 Aug 28;124(9):1379-80.
doi: 10.1182/blood-2014-07-587345.

Microbial messaging to the marrow

Stephanie S Watowich  1
Affiliations
Comment

Microbial messaging to the marrow

Stephanie S Watowich. Blood. .

Abstract

In this issue of Blood, Boettcher et al demonstrate that endothelial cell-intrinsic MyD88 signaling is critical for synthesis of the cytokine granulocyte colony-stimulating factor (G-CSF) and induction of emergency granulopoiesis during gram-negative bacterial infection. This work answers long-standing questions centered on which cell types transform systemic pathogen signals into the molecular cues needed to elicit neutrophil generation in demand situations.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Comment on

References

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