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Comment
. 2014 Aug 28;124(9):1382-3.
doi: 10.1182/blood-2014-07-586073.

ASXL genes and RUNX1: an intimate connection?

Klaus H Metzeler  1
Affiliations
Comment

ASXL genes and RUNX1: an intimate connection?

Klaus H Metzeler. Blood. .

Abstract

In this issue of Blood, Micol et al report the discovery of mutations in the additional sex combs-like 2 (ASXL2) gene in about one-quarter of acute myeloid leukemia (AML) patients carrying the t(8;21) translocation.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
ASXL gene mutations in t(8;21) AML. (A) ASXL2 is the second-most commonly mutated gene in AML with t(8;21). The heatmap visualizes the spectrum of recurrent gene mutations in 110 adult and pediatric patients with AML and t(8;21). ASXL2 and ASXL1 mutations were mutually exclusive. The figure has been adapted from Figure 1 in the article by Micol et al that begins on page 1445. (B) ASXL2 gene mutations do not affect overall survival in t(8;21) AML. The Kaplan-Meier curves depict overall survival of patients with mutated ASXL1, mutated ASXL2, or wild-type ASXL1/ASXL2. No difference between the 3 groups was observed. The figure has been adapted from supplemental Figure 4 in the article by Micol et al that begins on page 1445.
See this image and copyright information in PMC

Comment on

References

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    1. Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011;118(26):6920–6929. - PMC - PubMed

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