Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Aug 28;124(9):1383-4.
doi: 10.1182/blood-2014-06-576942.

Take (STAT)5: jazzing up T-cell leukemia

Affiliations
Comment

Take (STAT)5: jazzing up T-cell leukemia

Pierluigi Porcu et al. Blood. .

Abstract

In this issue of Blood, Kiel et al identify novel and high-frequency gain-of-function mutations involving genes of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway in T-cell prolymphocytic leukemia (T-PLL), paving the way for new targeted therapies.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Comment on

References

    1. Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG, Schrader A, Li B, Li JZ, Ozel AB, Betz BL, Miranda RN, Medeiros LJ, Zhao L, Herling M, Lim MS, Elenitoba-Johnson KS. Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood. 2014;124(9):1460-1472. - PMC - PubMed
    1. Pileri SA, Piccaluga PP. New molecular insights into peripheral T cell lymphomas. J Clin Invest. 2012;122(10):3448–3455. - PMC - PubMed
    1. Warner K, Crispatzu G, Al-Ghaili N, et al. Models for mature T-cell lymphomas—a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts. Crit Rev Oncol Hematol. 2013;88(3):680–695. - PubMed
    1. Mishra A, Liu S, Sams GH, et al. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell. 2012;22(5):645–655. - PMC - PubMed
    1. O’Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med. 2013;368(2):161–170. - PMC - PubMed