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Comment
. 2014 Aug 28;124(9):1385-6.
doi: 10.1182/blood-2014-06-581694.

What is a true ALCL?

Wolfram Klapper  1
Affiliations
Comment

What is a true ALCL?

Wolfram Klapper. Blood. .

Abstract

In this issue of Blood, Parrilla Castellar et al present a large cohort of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) in which they try to understand the diagnostic and the prognostic role of DUSP22 and TP63 in ALK-negative ALCL.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Overall survival in patients with ALCL, stratified by rearrangements of ALK, DUSP22, and TP63. −/−/−, triple-negative cases lacking all 3 rearrangements. See Figure 1B in the article by Parilla Castellar et al that begins on page 1473.
See this image and copyright information in PMC

Comment on

References

    1. Parilla Castellar ER, Jaffe ES, Said JW, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014;124(9):1473–1480. - PMC - PubMed
    1. Pileri S, Falini B, Delsol G, et al. Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes). Histopathology. 1990;16(4):383–391. - PubMed
    1. Pulford K, Lamant L, Morris SW, et al. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood. 1997;89(4):1394–1404. - PubMed
    1. Swerdlow SH, Campo E, Harris N, et al. Lyon, France: IARC; 2008. WHO Classification of Tumors of the Haematopoietic and Lymphoid Tissues.
    1. Feldman AL, Dogan A, Smith DI, et al. Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. 2011;117(3):915–919. - PMC - PubMed

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