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Comment
. 2014 Aug 28;124(9):1389-90.
doi: 10.1182/blood-2014-07-583898.

Primetime for γ'

David H Farrell  1
Affiliations
Comment

Primetime for γ'

David H Farrell. Blood. .

Abstract

In this issue of Blood, Omarova et al show that fibrinogen, particularly the γ′ variant, increases the anticoagulant effect of activated protein C in plasma.

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Conflict of interest statement

Conflict-of-interest disclosure: Oregon Health & Science University (OHSU) and David Farrell have a significant interest in Gamma Therapeutics, a company that may have a commercial interest in the results of this research and technology. This potential individual and institutional conflict of interest has been reviewed and managed by OHSU.

Figures

None
Alternative processing of the FGG gene pre-mRNA. The FGG 10 034C>T SNP (rs2066865) results in lower levels of γ′ fibrinogen. This SNP may affect the relative rate of spliceosome activity that cleaves out the ninth intron to form the γA isoform vs polyadenylation and cleavage activity that polyadenylates within the intron and cleaves the mRNA at the 3′ end of the polyadenylation site to form the γ′ isoform. Professional illustration by Xavier Studio.
See this image and copyright information in PMC

Comment on

References

    1. Omarova F, Uitte de Willige S, Simioni P, et al. Fibrinogen γ′ increases the sensitivity to activated protein C in normal and factor V Leiden plasma. Blood. 2014;124(9):1531-1538. - PubMed
    1. Uitte de Willige S, Standeven KF, Philippou H, Ariëns RA. The pleiotropic role of the fibrinogen γ′ chain in hemostasis. Blood. 2009;114(19):3994–4001. - PubMed
    1. Farrell DH. γ′ Fibrinogen as a novel marker of thrombotic disease. Clin Chem Lab Med. 2012;50(11):1903–1909. - PubMed
    1. Chung DW, Davie EW. γ and γ′ chains of human fibrinogen are produced by alternative mRNA processing. Biochemistry. 1984;23(18):4232–4236. - PubMed
    1. Lovely RS, Kazmierczak SC, Massaro JM, D’Agostino RB, Sr, O’Donnell CJ, Farrell DH. γ′ fibrinogen: evaluation of a new assay for study of associations with cardiovascular disease. Clin Chem. 2010;56(5):781–788. - PMC - PubMed