Comment

. 2014 Aug 28;158(5):971-972.

doi: 10.1016/j.cell.2014.08.010.

Neutralizing the HIV reservoir

Matthew D Marsden¹, Jerome A Zack²

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

PMID: 25171398
PMCID: PMC4182933
DOI: 10.1016/j.cell.2014.08.010

Comment

Neutralizing the HIV reservoir

Matthew D Marsden et al. Cell. 2014.

. 2014 Aug 28;158(5):971-972.

doi: 10.1016/j.cell.2014.08.010.

Authors

Matthew D Marsden¹, Jerome A Zack²

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

PMID: 25171398
PMCID: PMC4182933
DOI: 10.1016/j.cell.2014.08.010

Abstract

Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.

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Figures

**Figure 1**
HIV Reservoir Reduction in Humanized Mice Using Latency Activators and bNAbs

See this image and copyright information in PMC

Comment on

Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.
Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U, Furze RC, Seaman MS, Prinjha R, Tarakhovsky A, Ravetch JV, Nussenzweig MC. Halper-Stromberg A, et al. Cell. 2014 Aug 28;158(5):989-999. doi: 10.1016/j.cell.2014.07.043. Epub 2014 Aug 14. Cell. 2014. PMID: 25131989 Free PMC article.

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Neutralizing the HIV reservoir

Affiliations

Neutralizing the HIV reservoir

Authors

Affiliations

Abstract

Figures

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References

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LinkOut - more resources

Full Text Sources

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Medical