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Comment
. 2014 Aug 28;158(5):977-979.
doi: 10.1016/j.cell.2014.08.008.

Building a temperature-sensitive ion channel

Ming-Feng Tsai  1 , Christopher Miller  2
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Building a temperature-sensitive ion channel

Ming-Feng Tsai et al. Cell. .
Free article

Abstract

The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.

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