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. 2014 Oct 16;588(20):3732-8.
doi: 10.1016/j.febslet.2014.08.021. Epub 2014 Aug 27.

MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma

Xiaoming Qi  1 , Jianqiang Li  1 , Changbo Zhou  1 , Chunlei Lv  1 , Min Tian  2
Affiliations
Free article

MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma

Xiaoming Qi et al. FEBS Lett. .
Free article

Abstract

In the present study, we investigated the roles and molecular mechanisms of miR-320a in human nasopharyngeal carcinoma (NPC). miR-320a expression was strongly reduced in NPC tissues and cell lines. Overexpression of miR-320a significantly suppressed NPC cell growth, migration, invasion and tumor growth in a xenograft mouse model. A luciferase reporter assay revealed that miR-320a could directly bind to the 3' UTR of BMI-1. Overexpression of BMI-1 rescued miR-320a-mediated biological function. BMI-1 expression was found to be up-regulated and inversely correlated with miR-320a expression in NPC. Collectively, our data indicate that miR-320a plays a tumor suppressor role in the development and progression of NPC and may be a novel therapeutic target against NPC.

Keywords: BMI-1; Invasion; Nasopharyngeal carcinoma; Proliferation; miR-320a.

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