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Review
. 2015 May;48(7-8):472-5.
doi: 10.1016/j.clinbiochem.2014.08.014. Epub 2014 Aug 27.

A review on lecithin:cholesterol acyltransferase deficiency

Ramesh Saeedi  1 , Min Li  2 , Jiri Frohlich  3
Affiliations
Review

A review on lecithin:cholesterol acyltransferase deficiency

Ramesh Saeedi et al. Clin Biochem. 2015 May.

Abstract

Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal opacities, changes in erythrocyte morphology and renal failure. Recombinant LCAT is being developed for the treatment of patients with LCAT deficiency.

Keywords: Cholesterol; FED; FLD; HDL; LCAT deficiency.

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