Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov 30;224(2):107-11.
doi: 10.1016/j.pscychresns.2014.07.009. Epub 2014 Aug 15.

Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study

Drew Barzman  1 , Jim Eliassen  2 , Robert McNamara  3 , Pablo Abonia  4 , Douglas Mossman  3 , Michele Durling  3 , Caleb Adler  2 , Melissa DelBello  1 , Ping-I Lin  5
Affiliations

Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study

Drew Barzman et al. Psychiatry Res. .

Abstract

The mechanisms underlying aggression in adolescents with bipolar disorder have been poorly understood. The present study has investigated the associations among TNF gene expressions, functional brain activations under the frustrative non-reward task, and aggression in adolescents with bipolar disorder. Baseline gene expressions and aggressive tendencies were measured with the RNA-sequencing and Brief Rating of Aggression by Children and Adolescents (BRACHA), respectively. Our results show that activity levels of left subgenual anterior cingulate gyrus (ACG), right amygdala, left Brodmann area 10 (orbitofrontal cortex), and right thalamus were inversely correlated with BRACHA scores and were activated with frustrative non-reward during the affective Posner Task. In addition, 11 TNF related gene expressions were significantly correlated with activation of amygdala or ACG during the affective Posner Task. Three TNF gene expressions were inversely correlated with BRACHA score while one TNF gene (TNFAIP3) expression was positively correlated with BRACHA score. Therefore, TNF-related inflammatory cytokine genes may play a role in neural activity associated with frustrative non-reward and aggressive behaviors in pediatric bipolar disorder.

Keywords: Amygdala; Anterior cingulate gyrus; Frustrative non-reward; Prefrontal cortex; RNA-sequencing; Tumor necrosis factor.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Changes in Arousal, Mood, and Dominance with the Affective Posner Task based on Self-Ratings
See this image and copyright information in PMC

References

    1. Barzman D, Mossman D, Sonnier L, Sorter M. Brief Rating of Aggression by Children and Adolescents (BRACHA): a reliability study. The journal of the American Academy of Psychiatry and the Law. 2012;40:374–382. - PubMed
    1. Barzman DH, Brackenbury L, Sonnier L, Schnell B, Cassedy A, Salisbury S, Sorter M, Mossman D. Brief Rating of Aggression by Children and Adolescents (BRACHA): development of a tool for assessing risk of inpatients' aggressive behavior. The journal of the American Academy of Psychiatry and the Law. 2011;39:170–179. - PubMed
    1. Bradley MM, Lang PJ. Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. Journal of behavior therapy and experimental psychiatry. 1994;25:49–59. - PubMed
    1. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Computers and biomedical research, an international journal. 1996;29:162–173. - PubMed
    1. Cox RW, Hyde JS. Software tools for analysis and visualization of fMRI data. NMR in biomedicine. 1997;10:171–178. - PubMed

Publication types

LinkOut - more resources