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. 2014 Oct 1;193(7):3463-9.
doi: 10.4049/jimmunol.1400797. Epub 2014 Aug 29.

Transcriptional characterization of the T cell population within the salmonid interbranchial lymphoid tissue

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Transcriptional characterization of the T cell population within the salmonid interbranchial lymphoid tissue

Ida Bergva Aas et al. J Immunol. .

Erratum in

  • J Immunol. 2014 Dec 15;193(12):6207

Abstract

Previously, our group has shown that the interbranchial lymphoid tissue (ILT) is a distinct structure largely consisting of T cells embedded in a meshwork of epithelial cells, with no direct resemblance to previously described lymphoid tissues. In this study, we aim to focus on the T cell population and the possibility of the ILT being a thymus analog. By characterizing structural responsiveness to Ag challenge, the presence of recombination activating genes, and different T cell-related transcripts, we attempt to further approach the immunological function of the ILT in salmonid gills. In addition to eight healthy individuals, a group of eight infectious salmon anemia virus-challenged fish were included to observe T cell responses related to infection. The results showed reduced size of ILT in the infected group, no expression of RAG-1 and -2, and a high degree of T cell diversity within the ILT. Taking into account that the ILT can be regarded as a strategically located T cell reservoir and possibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, the alteration in transcription observed may likely represent a shift in the T cell population to optimize local gill defense mechanisms.

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